You fools, you'll kill us all! Wait, Pac-Man? Oh, carry on then. A team at Stanford Bioengineering's Riedel-Kruse Lab have mixed digital overlays and electrically controlled microorganisms to make playable games.
The team used a single-celled protozoans called paramecia which swims about using tiny wafting hairs on its body. By changing electical currents it's possible to influence its direction. The scientists then used image processing software to add on game like enlightenment, Pac-Man, football and Breakout. (Via animalnewyork.com.)
It looks a lot like this: